Meeting programme

Wednesday 27 September 2023

12:00 - 14:00              Registration

14:00 - 14:15              Opening of the meeting - Introduction

Session I                   Chairs: Tanya Paull & Ludovic Deriano

14:15 - 14:40              Joseph Loparo

                                   Stochastic Assembly of the NHEJ Machinery

14:40 - 15:00              Duc Duy Vu

                                   Interactions of intrinsically disordered protein regions in NHEJ: going beyond short                                      linear binding motifs with chemical-exchange NMR

15:00 - 15:20              Jamie Phipps

                                   Cohesin complex oligomerization maintains genome integrity at DNA double-strand                                    breaks

15:20 - 15:45              Terence Strick

                                   Single-molecule analysis of NHEJ across species

15:45 - 16:15              Coffee break

16:15 - 16:40              Amanda Chaplin

                                   NHEJ complexes come in all shapes and sizes

16:40 - 17:00              Richard Frock

                                   DNA-PKcs Suppresses Illegitimate Chromosome Rearrangements

17:00 - 17:20              Karim Ben Ali Gacem

                                   Structural and biophysical study of inhibitors of Ku-DNA interactions

17:20 - 17:45              Yuan He

                                   Structural Basis of DNA double-strand break repair by NHEJ

Thursday 28 September 2023

Session II                  Chairs: Gaëlle Legube & Yuan He

09:55 - 10:15              Julien Bischerour

                                   Ku70/80 and Paxx homologs couple DNA repair to programmed double-strand                                            breaks to ensure faithful assembly of the Paramecium somatic genome

10:15 - 10:35              Zhou Xu

                                   Functions of the Cdc13-Stn1-Ten1 (CST) complex in double-strand break repair

10:35 - 11:00              Coffee break

11:00 - 11:05              Thermo Fisher Scientific (Sponsor)

                                   Cool Insights: Exploring Biomolecular Structures with Cryo-EM

11:05 - 11:30              Ludovic Deriano

                                   Alternative repair of DNA double-strand breaks in recombining lymphocytes

11:30 - 11:50              Emmanuelle Martini

                                   Switching from Homologous Recombination to End Joining allows oocytes to                                                survive radiation

11:50 - 12:10              Jaroslav Fulnecek

                                   Chemical inhibition of human Ku leads to excision of extrachromosomal telomeric                                        circles and cell cycle arrest in S-phase

12:10 - 12:30              Adam Luthman

                                   Distinct mechanisms for repair of each strand of a double strand break by NHEJ

12:30 - 13:30              Lunch

13:30 - 15:00              Poster session

Session III                 Chairs: Sarah Lambert & Joseph Loparo

15:00 - 15:25              Éric Gilson

                                   The RAP1-TRF2 duo in preventing NHEJ at telomeres

15:25 - 15:45              Stefano Mattarocci

                                   Telomere Protection by Ku Translocation Inhibition at the Tips of Telomeres

15:45 - 16:05              Max Douglas

                                   Direct inhibition of NHEJ by the Shelterin subunits TRF2 and Rap1

16:05 - 16:30              Tanya Paull

                                   Interplay between NHEJ factors and MRN at DNA double-strand breaks

16:30 - 16:55              Coffee break

16:55 - 17:00              Dynamic Biosensors GmbH (Sponsor)

                                   How to characterize the molecular interactions driving DNA repair using                                                       switchSENSE®

17:00 - 17:25              Karine Dubrana

                                   Heterochromatin regulates DSB resection and DNA repair pathway choice

17:25 - 17:45              Satish K. Tadi

                                   Molecular role of Ku in maintaining and regulating V(D)J recombination

17:45 - 18:10              Dale Ramsden

                                   The last poorly understood DNA repair pathway…now pretty well understood?

Friday 29 September 2023

Session IV                 Chairs: Wei Yang & Eric Gilson

09:30 - 09:55              Sarah Lambert

                                   KU hugs DNA-embedded RNAs to maintain replication fork integrity

09:55 - 10:15              Aditya Mojumdar

                                   Dna2 nuclease resolves end-joining promoting RNA:DNA hybrids at double-strand                                      breaks

10:15 - 10:35              Erica Salvati

                                   ALT human cancers require Alt-NHEJ to cope with replication stress at telomeres

10:35 - 11:00              Mauro Modesti

                                   Multivalent interactions of the disordered regions of XLF and XRCC4 foster robust                                      cellular NHEJ and drive the formation of ligation-boosting condensates in vitro

11:00 - 11:30              Coffee break

11:30 - 11:55              Gaëlle Legube

                                   Chromosome and chromatin dynamics at DNA Double Strand Breaks

11:55 - 12:15              Francisca Lottersberger

                                   Nuclear deformability mediates DSBs repair by affecting chromatin mobility

12:15 - 12:40              Eli Rothenberg

                                   Organization and dynamics of the human NHEJ machinery during repair

12:40 - 13:30              Lunch

13:30 - 14:30              Poster session

Session V                  Chairs: Karine Dubrana & Terence Strick 

14:30 - 14:55              Josée Guirouilh-Barbat

                                   Mammalian homologous recombination protein RAD51 promotes genome instability                                    in a homology-independent manner

14:55 - 15:15              Angel Rivera-Calzada

                                   Structural bases of the inactivation of NHEJ proteins by the vaccinia virus

15:15 - 15:40              Thomas Wilson

                                   Genomic analysis of large deletions induced at common fragile sites by replication                                      stress

15:40 - 16:10              Coffee break

16:10 - 16:30              Haser Sutcu

                                   Decline of DNA Damage Response along with Myogenic Differentiation

16:30 - 16:55              Erika Brunet

                                   Chromosomal translocations in primary human cells during oncogenesis

16:55 - 17:30              Meeting discussion and concluding remarks

17:30                          End of the meeting